COMPARISON OF MEDIAL TEMPORAL LOBE MEASUREMENTS ON MRI AMONG ALZHEIMER’S GERIATRIC PATIENTS: A CROSS-SECTIONAL STUDY

Abdulwahab Faiz Alahmari

Abstract


ABSTRACT

BACKGROUND

Alzheimer’s is a syndrome mostly affecting geriatric causing medial temporal lobe atrophy and memory impairment. It is untreatable in geriatrics patients, but lack of using simple and reliable measurements to determine the severity of Alzheimer’s disease. This paper collects the severity of Alzheimer’s geriatric patients based on the popular visual grading system MTA, linear measurements applied on MRI scan to determine the severity of Alzheimer’s disease, and the reliability and repeatability of these measurements.

OBJECTIVES

The aims of this study are to find the common grade of Alzheimer’s disease by using a simple and reliable measurement, find the reliability and repeatability of hippocampal linear measurements. Find the relation of the grade of atrophy with gender, and age. Measure hippocampal height and width to give a reference value of Alzheimer’s patient and measure radial temporal horn width and compare between right and left side. Compare between the United States and international Alzheimer’s patients.

METHODOLOGY

A cross-sectional study was conducted on 60 geriatric Alzheimer’s subjects from ADNI database which represent 5 % of all Alzheimer’s population in the United States. By using a visual grading system which is applied on MRI scan and compare them to each other. Statistical analysis was done by SPSS (V-21) software. The aim of this paper is to find the most common grade and the relation between the grade of Alzheimer’s with gender and age. Give reference value of mean volume for both right and left hippocampus. Compare between right and left temporal horn width.

RESULT

The aim of this paper was to find the most common grade of Alzheimer’s disease among ADNI database which was done on 60 patients from ADNI. The most common grade is grade one and Alzheimer is more common in males, but it is more severe in females. MTA grading system must change from visual grading system to a system that depends on measurable values. The new MTA system must include hippocampal width since hippocampal width has a higher association with MTA more than the hippocampal height. RR can be used as criteria to verify the grade of the new MTA.  

CONCLUSION

The suggestions and recommendations for future studies are to focus on transforming the MTA grading system to a system that depends on measurable values. Add the width of the hippocampus to the MTA grading system criteria. Provide simple software’s that can measure the hippocampal volume in a simple clinical sitting. 

KEYWORDS

Alzheimer’s, Geriatrics, MRI.


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References


References

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