Asma Javed, Sheeraz Ahmed Sheikh, Shahabuddin Siddiqui, Qaiser Ali


Pituitary stalk interruption syndrome is a rare congenital abnormality that arises during embryogenesis as a result of defective neuronal migration. It is one of the common cause of pituitary dwarfism. A 17 years old male patient from Pakistan who presented with short stature and absence of secondary sexual characteristics. On physical examination, the height and weight of the patient was below than standard. The hormonal profile showed significantly reduced levels of anterior pituitary hormones and increased prolactin levels. The bone age was less than the chronological age of the patient. MR findings of patient showed hypoplasia of anterior pituitary, total absence of the infundibulum (pituitary stalk), absence of the posterior pituitary bright spot in its normal location and an ectopic posterior pituitary seen at the median eminence exhibiting high signal on T1WI and T2WI. The findings were consistent with the diagnosis of pituitary stalk interruption syndrome.

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