TO DETERMINE FREQUENCY OF INCIDENTAL FINDING OF CAROTID INTIMA MEDIA THICKNESS >1MM IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND COMPARE SEVERITY OF HEPATIC STEATOSIS WITH INCREASED CAROTID INTIMA MEDIA THICKNESS >1MM

Dr Ayesha Hanif, Dr Atique Ur Rehman Slehria, Dr Mobeen Shafique, Dr Muhammad Usman Khan, Dr Muhammad Omer Aamir, Dr Umer Kaleem, Dr syed Aown Raza Shah Bokhari, Dr Mehwish Razzaq

Abstract


Abstract:

Introduction: Ultrasonography has become widespread diagnostic tool and presently it is the preferable method for diagnosing patients with nonalcoholic fatty liver disease as it is noninvasive, in expensive and widely available.

Objectives: To determine frequency of incidental finding of Carotid Intima media thickness >1mm in patients with Non-Alcoholic Fatty liver disease and compare severity of hepatic steatosis with increased carotid intima media thickness >1mm.

Materials & Methods: This Descriptive, cross-sectional study was conducted from  26th December 2017 to 25th June 2018 in the department of radiology ,Armed Forces of Radiology and Imaging, military hospital, Rawalpindi. A total of 96 patients having fatty liver on ultrasound scan, 18 to 70 years of age were included. Patients with history of alcohol ingestion, renal disease or stigmata of chronic liver disease and previous diagnosis of stroke or Transient ischemic attack were excluded. After taking informed consent and relevant history, patient was guided to take ultrasound scan of the abdomen and duplex ultrasound scan of carotids in order to assess the hepatic steatosis and carotid intima media thickness measurement.

Results: Mean age was 50.80 ± 9.64 years. Out of the 96 patients, 48 (50.0%) were male and 48 (50.0%) were females with male to female ratio of 1:1. Majority of patients were with grade I i.e. 44 (45.83%). Frequency of incidental finding of Carotid Intima media thickness >1mm in patients with Non-Alcoholic Fatty liver disease was found in 55 (57.29%) patients.

Conclusion: This study concluded that frequency of incidental finding of Carotid Intima media thickness >1mm in patients with Non-Alcoholic Fatty liver disease is very high.

Keywords: Non-Alcoholic Fatty liver disease, common carotid artery, intima media thickness.

Full Text:

PDF

References


References:

Ekstedt M, Hagstrom H, Nasr P, Fredrikson M, Stal P, Kechagias S, et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 2015;61:1547–1554.

Pais R, Giral P, Khan JF, Rosenbaum D, Housset C, Poynard T, Ratziu V . Fatty liver is an independent predictor of early carotid atherosclerosis. LIDO Study Group .J Hepatol. 2016;65:95-102.

Musso G, Gambino R, Cassader M. Need for a three-focused approach to nonalcoholic fatty liver disease. Hepatology 2004;53(5), 1773; author reply 1774.

Stepanova M, Younossi ZM. Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population. Clin. Gastroenterol. Hepatol. 2012;10(6):646–650.

Rafiq N, Bai C, Fang Y et al. Long-term follow-up of patients with nonalcoholic fatty liver. Clin. Gastroenterol. Hepatol. 2009;7(2):234–238.

Stepanova M, Rafiq N, Younossi ZM. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut 2010;59(10):1410–1415.

Adams LA, Lymp JF, St Sauver J et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129(1):113–121.

AlShaalan R, Aljiffry M, Al-Busafi S, Metrakos P, Hassanain M. Nonalcoholic Fatty Liver Disease: Noninvasive Methods of Diagnosing Hepatic Steatosis. Saudi J Gastroenterol . 2015;21(2):64-70.

Guth S, Windler E, Leise U, Bamberger CM. Ultrasound Diagnosis of Hepatic Steatosis as a Surrogate for Atherosclerosis. Ultrasound Int Open. 2016;2(1):E27-E31. DOI: 10.1055/s-0035-1569419.

Metin kukukazman,Naim Ata. Evaluation of early Atherosclerosis markers in patients with non alcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2013; DOI:10.1097/MEG.0b013e32835a58b1.

Emel, Torn, Sinem Ayden,Selim Gokce,Ikler Tolga Ozgen, Tugrul Donmez. Carotid intima-media thickness and flow-mediated dilation in obese children with non-alcoholic fatty liver disease Turk J Gastroenterol. 2014; 25: 92 DOI:10.5152/tjg.2014.5552.

Kang JH, Cho KI, Kim SM. Relationship between Nonalcoholic Fatty Liver Disease and Carotid Artery Atherosclerosis Beyond Metabolic Disorders in Non-Diabetic Patients. J Cardiovasc Ultrasound. 2012;20(3):126-133.

Park SH, Jeon WK, Kim SH, Kim HJ, Park DI, Cho YK, Sung IK, Sohn CI, Keum DK, Kim BI. Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults. J Gastroenterol Hepatol. 2006;21(1 Pt 1):138–143.

Choi SY, Kim D, Kang JH, Park MJ, Kim YS, Lim SH, Kim CH, Lee HS. [Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease: relation of non-alcoholic fatty liver disease to carotid atherosclerosis] Korean J Hepatol. 2008;14:77–88.

Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221–1231.

Adams LA, Angulo P. Recent concepts in non-alcoholic fatty liver disease. Diabet Med. 2005;22:1129–1133.

McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis. 2004;8:521–533. viii.

Targher G, Bertolini L, Padovani R, Zenari L, Zoppini G, Falezza G. Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation. Diabetes Care. 2004;27:2498–2500.

Aygun C, Kocaman O, Sahin T, Uraz S, Eminler AT, Celebi A, Senturk O, Hulagu S. Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Dig Dis Sci. 2008;53:1352–1357.

Targher G, Bertolini L, Rodella S, Tessari R, Zenari L, Lippi G, Arcaro G. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care. 2007;30:2119–2121.

Musso G, Gambino R, Bo S, Uberti B, Biroli G, Pagano G, Cassader M. Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects. Diabetes Care. 2008;31:562–568.

Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes. 2001;50:1844–1850.

Kim HC, Kim DJ, Huh KB. Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. Atherosclerosis. 2009;204:521–525.

Jeong JW. Intima-media thickness of the carotid artery: non-invasive marker of atherosclerosis. J Korean Soc Echocardiogr. 2002;10:8–12.

O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK, Jr Cardiovascular Health Study Collaborative Research Group. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999;340:14–22.

Park BH, Yoon GH, Park JH, Choi CS, Kook H, Yoo NJ, Oh SG, Jung JW, Park YG, Park OG. Relation of carotid artery intima-media thickness and atherosclerotic plaque with the extent of coronary artery stenosis. J Korean Soc Echocardiogr. 2000;8:45–53.

Volzke H, Robinson DM, Kleine V, Deutscher R, Hoffmann W, Ludemann J, Schminke U, Kessler C, John U. Hepatic steatosis is associated with an increased risk of carotid atherosclerosis. World J Gastroenterol. 2005;11:1848–1853

Lankarani KB, Mahmoodi M, Lotfi M, Zamiri N, Heydari ST, Ghaffarpasand F, et al. Common carotid intima-media thickness in patients with non-alcoholic fatty liver disease: a population-based case-control study. Korean J Gastroenterol. 2013 Dec;62(6):344-51.

Shaikh AH, Aatif S, Ahmed T. Carotid Intima-Media Thickness in Patients with Non-Alcoholic Fatty Liver Disease. Journal of Basic & Applied Sciences, 2013;9:333-336.

Targher G, Bertolini L, Padovani R. Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease. Diabetes Care 2006;29:1325–30.

O’Leary DH, Polak JF, Kronmal RA. Distribution and correlates of sonographically detected carotid artery disease in the Cardiovascular Health Study. The CHS Collaborative Research Group. Stroke 1992;23:1752–60.


Refbacks

  • There are currently no refbacks.


© Copyright PJR 2008-