Maria rauf


Neuroradiology remains the most fascinating dimension of radiology; encompassing a variety of interesting radiological signs manifested in the brain with particular neurological disease. Interestingly most of these signs resemble different animals, birds or insects in the brain. Understanding and recognizing these signs aids in successful interpretation of the scans and aids in establishing appropriate diagnosis.


The aim of this study is to illustrate these typical neuro-radiological signs resembling various animals and to briefly outline the underlying pathogenesis. 



We compiled all these cases with interesting neuro-radiological signs manifested on MRI brain performed at Shifa international hospital, Islamabad from January 2016- December 2019. These include:

  1. Hallervorden Spatz disease; eye of tiger sign
  2. Wilson disease; Face of the giant Panda sign
  3. Central pontine myelinolysis; Owl eye appearance
  4. Glioma; Butterfly sign
  5. Joubert syndrome; Bat wing fourth ventricle
  6. Metachromic leukodystrophy; Tigroid pattern
  7. Dysplastic cerebellar gangliocytoma; Tigroid or leopard skin pattern
  8. Meningioma: Tail sign
  9. Corpus callosum agenesis; steer horn ventricles

10.Penguin sign; Progressive supranuclear palsy

11.Caput medusa; DVA.




Knowledge of these easily decipherable animal based signs in brain is important as it helps in narrowing down the elaborate list of differentials and also facilitates in making imaging based diagnosis.



Key words: neuroradiology, Wilson disease, Joubert syndrome, Glioma, Corpus callosum agenesis.

Full Text:



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