Sadia Khurshid, Sadia Khurshid



Objective: We intend to evaluate the relationship between biomarkers (C- reactive protein (CRP), lactate dehydrogenase (LDH), D-dimers & ferritin) & CT scan chest grade (COVID-RADS).

Study Design: Retrospective study

Place & duration of study: Liaquat National Hospital,Karachi,Pakistan during April 2020 to November 2020. 


All patients with suspected COVID-19 pneumonia who went through CT scan chest in Liaquat National Hospital in the mentioned time period were included in the study. Their electronic medical records was reviewed for the levels of laboratory biomarkers and CT findings were analyzed using the COVID-19 imaging reporting and data system (COVID-RADS) for grading of CT findings into five grades.


In total, 80 patients, including 60 males and 20 females with COVID-19 pneumonia, were part of our study.Serum LDH and ferritin levels were elevated in 69(90.8%) and 63(81.8%) patients respectively.C-reactive protein was elevated in 34(45.3%) patients.57(82.6%) patients had elevated D- dimer levels. 65(81.3%) and  52 (72.5%) patients presented with typical and atypical chest findings respectively. Most of the patients had grade 2B chest findings 62(77.5%).

3(76.8%) and 11(15.9%) patients had raised LDH level in grade 2B and 3 respectively. 51(81%) and 9 (14.3%) patients had raised ferritin in grade 2B and 3 respectively. D-dimer was elevated in 44(77.2%) and 8(14%) patients in grade 2B and 3 respectively. 26(76.5%) and 6(17.6%) patients had raised C-reactive protein in grade 2B and 3 respectively.


We found no association of laboratory biomarkers with CT chest COVID -RADS grading so there can be a possibility that the patients have raised lab biomarkers but it doesn’t correlate with the grade of COVID-RADS.


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