CO-RELATION OF CHEST CT GRADE BY COVID-RADS AND LABORATORY BIOMARKERS IN SUSPECTED CORONA VIRUS (COVID-19) PNEUMONIA PATIENTS –OUR EXPERIENCE AT A TERTIARY CARE HOSPITAL

Sadia Khurshid; Sadia Khurshid

CO-RELATION OF CHEST CT GRADE BY COVID-RADS AND LABORATORY BIOMARKERS IN SUSPECTED CORONA VIRUS (COVID-19) PNEUMONIA PATIENTS –OUR EXPERIENCE AT A TERTIARY CARE HOSPITAL

Sadia Khurshid, Sadia Khurshid

Abstract

ABSTRACT:

Objective: We intend to evaluate the relationship between biomarkers (C- reactive protein (CRP), lactate dehydrogenase (LDH), D-dimers & ferritin) & CT scan chest grade (COVID-RADS).

Study Design: Retrospective study

Place & duration of study: Liaquat National Hospital,Karachi,Pakistan during April 2020 to November 2020.

Methodology:

All patients with suspected COVID-19 pneumonia who went through CT scan chest in Liaquat National Hospital in the mentioned time period were included in the study. Their electronic medical records was reviewed for the levels of laboratory biomarkers and CT findings were analyzed using the COVID-19 imaging reporting and data system (COVID-RADS) for grading of CT findings into five grades.

Results:

In total, 80 patients, including 60 males and 20 females with COVID-19 pneumonia, were part of our study.Serum LDH and ferritin levels were elevated in 69(90.8%) and 63(81.8%) patients respectively.C-reactive protein was elevated in 34(45.3%) patients.57(82.6%) patients had elevated D- dimer levels. 65(81.3%) and 52 (72.5%) patients presented with typical and atypical chest findings respectively. Most of the patients had grade 2B chest findings 62(77.5%).

3(76.8%) and 11(15.9%) patients had raised LDH level in grade 2B and 3 respectively. 51(81%) and 9 (14.3%) patients had raised ferritin in grade 2B and 3 respectively. D-dimer was elevated in 44(77.2%) and 8(14%) patients in grade 2B and 3 respectively. 26(76.5%) and 6(17.6%) patients had raised C-reactive protein in grade 2B and 3 respectively.

Conclusion:

We found no association of laboratory biomarkers with CT chest COVID -RADS grading so there can be a possibility that the patients have raised lab biomarkers but it doesn’t correlate with the grade of COVID-RADS.

Full Text:

PDF

References

REFERENCES:

COVID-19 Worldwide dashboard WHO live world stastics WHO Coronavirus Disease (COVID-19) DashboardData last updated: 2020/12/7, 10:21am CEST

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20(4):425-34.

Pierce JD, McCabe S, White N, Clancy RL. Biomarkers: an important clinical assessment tool. Am J Nurs. 2012;112(9):52-8.

Gong J, Dong H, Xia SQ, Huang YZ, Wang D, Zhao Y, Liu W, et al. Correlation analysis between disease severity and inflammation-related parameters in patients with COVID-19 pneumonia. Med Rxiv. 2020;1:1-17.

World Health Organization (2020) Coronavirus disease (COVID19) technical guidance: laboratory testing for 2019-nCoV in humans. World Health Organization, Geneva Available via https://www.who.int/emergencies/diseases/novel-coronavirus2019/technical-guidance/laboratory-guidance. Accessed 26 Mar 2020

Ye G, Li Y, Lu M, Chen S, Luo Y, Wang S, et al. Experience of different upper respiratory tract sampling strategies for detection of COVID-19. J Hosp Infect. 2020;105(1):1-2.

Pan Y, Guan H, Zhou S, Wang Y, Li Q, Zhu T, et al. Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China. Europ Radiol. 2020;30(6):3306-9.

China National Health Commission website. Notice on issuing a new coronavirus infected pneumonia diagnosis and treatment plan (trial version5).bgs.satcm.gov.cn/zhengcewenjian/2020-02-06/12847. html. Published February 4, 2020. Accessed February 18, 2020

Huang P, Liu T, Huang L, Liu H, Lei M, Xu W, et al. Use of chest CT in combination with negative RT-PCR assay for the 2019 novel coronavirus but high clinical suspicion. Radiol. 2020;295(1):22-3.

Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for typical coronavirus disease 2019 (COVID-19) pneumonia: relationship to negative RT-PCR testing. Radiol. 2020;296(2):41-5.

Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19)imaging reporting and data system (COVID-RADS) and common lexicon: a proposal based on theimaging data of 37 studies. EurRadiol. 2020;30:4930-42.

Salehi S. abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus disease 2019 (COVID-19, 2019-nCoV): a systematic review of imaging findings in 919 patients. Am J Roentgenol. 2020:215(1);1–7.

Pan Y, Guan H. Imaging changes in patients with 2019-nCov. Europ Radiol. 2020:30;3612–3

Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A. The role of biomarkers in diagnosis ofCOVID-19–A systematic review. Life Sci. 2020;254:117-788.

Velavan TP, Meyer CG. Mild versus severe COVID-19: laboratory markers. Intern J Infect Dis. 2020;95:304-7.

Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intens Care Med. 2020;46(5):846-8.

Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-7.

Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20(4)425-34

Vancheri SG, Savietto G, Ballati F, Maggi A, Canino C, Bortolotto C, et al. Radiographic findingsin 240 patients with COVID-19 pneumonia:time-dependence after the onset of symptoms.EurRadiol. 2020;1:6161-9

Refbacks

There are currently no refbacks.