Gul sanam, Anashia kayani, Zafar Amin, Raheel khan, Najwa Zahoor, Tehmina irshad, zainab shehzadi


Objectives: To determine the diagnostic accuracy of contrast enhanced CT scan in diagnosing bronchogenic carcinoma, taking histopathology as gold standard.

Study design: Cross-sectional validation study.

Setting: Department of Radiology, Armed Forces Institute of Radiology, Rawalpindi from 8th December 2020 to 7th June 2021

Methodology: A total of 148 patients with suspected bronchogenic carcinoma between 20-70 years of age were included. Patients with already taking treatment, CRF and h/o allergy to contrast agent were excluded. Then CT was performed on Toshiba Asteion Multi Slice Scanner with I/V contrast. CT scan findings were interpreted by one consultant radiologist (at least 5 years of experience) and was looked for bronchogenic carcinoma as per-operational definition. All patients were then undergone CT guided transthoracic biopsy of pulmonary lesions by the relevant interventional radiologist and specimen was sent to institutional pathology laboratory for histopathology.

Results: Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of contrast enhanced CT scan in diagnosing bronchogenic carcinoma, taking histopathology as gold standard was 94.32%, 91.67%, 94.32%, 91.67% and 93.24% respectively.

Conclusion: This study concluded that the diagnostic accuracy of contrast enhanced CT scan in diagnosing bronchogenic carcinoma is very high. 

Keywords: bronchogenic carcinoma, computed tomography, sensitivity.

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