DIAGNOSTIC ACCURACY OF SPECTRAL DOPPLER ULTRASOUND IN DIFFERENTIATING BETWEEN BENIGN AND MALIGNANT SOLID BREAST LESIONS TAKING HISTOPATHOLOGY AS GOLD STANDARD
Abstract
Abstract:
Objective:
To determine the diagnostic accuracy of spectral doppler ultrasound in predicting malignancy in evaluation of solid breast lesions taking histopathology as gold standard. Materials and methods: This cross Sectional Validation Study was conducted at Radiology Department, KRL Hospital, Islamabad for six months from1st August 2021 to 31st January 2022. A total of 145 women with solid breast lesions of BI-RADS category scale III-V were included in the study. All women underwent spectral doppler ultrasound of breast and malignancy was considered positive if spectral doppler US image shows resistive index (RI)= 0.68. These patients were then subjected to histopathology. The data was collected on a predesigned proforma and results were analyzed by using the SPSS software version 17.0 by descriptive and inferential statistics.
Results:
In this study age range was 18 to 60 years with mean age of 42.965±7.66 years. Spectral doppler ultrasound has shown sensitivity of 84.8%, specificity 95% and diagnostic accuracy by 92%, PPV 88.6% and NPV 93% in diagnosis of malignant breast lesion.
Conclusion:
In conclusion, Doppler examination has a significant role in the evaluation of solid breast lesions for distinguishing malignant tumors from benign lesions.
Keywords:
Solid breast lesions, Spectral doppler ultrasound, Histopathology, Diagnostic accuracy
Full Text:
PDFReferences
References:
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, et al. American cancer society/American society of clinical oncology breast cancer survivorship care guideline. Cancer J Clin. 2016;66(1):43-73.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. Cancer J Clin. 2019;69(1):7-34.
Berry DA, Cronin KA, Plevritis SK, Fryback DG, Clarke L, Zelen M, et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med. 2015;353:1784-92.
Gokalp G, Topal U, Kizilkaya E. Power Doppler sonography: Anything to add to BI-RADS US in solid breast masses? Eur J Radiol. 2019;70:77-85.
Del Cura JL, Elizagaray E, Zabala R, Legórburu A, Grande D. The use of unenhanced Doppler sonography in the evaluation of solid breast lesions. AJR Am J Roentgenol. 2015;184:1788-94.
Kwak JY, Kim EK, Kim MJ, Choi SH, Son E, Oh KK. Power Doppler sonography: Evaluation of solid breast lesions and correlation with lymph node metastasis. Clin Imaging. 2018;32:167-71.
Cho N, Jang M, Lyou CY, Park JS, Choi HY, Moon WK. Distinguishing benign from malignant masses at breast US: Combined US elastography and color doppler US — influence on radiologist accuracy. Radiology 2012;262:80-90.
Stuhrmann M, Aronius R, Schietzel M. Tumor vascularity of breast lesions: Potentials and limits of contrast-enhanced Doppler sonography. AJR Am J Roentgenol. 2015;175:1585-9.
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 2015; 285:1182-6.
Milz P, Lienemann A, Kessler M, Reiser M. Evaluation of breast lesions bypower Doppler sonography. EurRadiol. 2001;11:547-54.
Ibrahim R, Rahmat K, Fadzli F, Rozalli FI, Westerhout CJ, Alli K, Vijayananthan A, Moosa F. Evaluation of solid breast lesions with power Doppler: value of penetrating vessels as a predictor of malignancy. Singapore Med J. 2016;57(11):634-9.
Sirous M, Sirous R, Nejad FK, Rabeie E, Mansouri M. Evaluation of different aspects of power Doppler sonography in differentiating and prognostication of breast masses. J Res Med Sci. 2015;20(2):133-7.
Keshavarz E, Zare-Mehrjardi M, Karimi MA, Valian N, Kalantari M, et al. Diagnostic value of spectral doppler ultrasound in detecting breast malignancies: an original article. Int J Cancer Manag. 2018;11(2):e8200.
BergWA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Bohm-Velez M, et al. Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA. 2008;299(18):2151–63. doi: 10.1001/jama.299.18.2151. [PubMed: 18477782].
89. Sickles EA. Imaging techniques other than mammography for the detection and diagnosis of breast cancer. Recent Results Cancer Res. 1990;119:127–35. [PubMed: 2236853].
90. ChaoTC, Lo YF,ChenSC,ChenMF. Color Doppler ultrasound in benign and malignant breast tumors. Breast Cancer Res Treat. 1999;57(2):193–9. [PubMed: 10598046].
91. Svensson WE, Pandian AJ, Hashimoto H. The use of breast ultrasound color Doppler vascular pattern morphology improves diagnostic sensitivity with minimal change in specificity. Ultraschall Med. 2010;31(5):466–74. doi: 10.1055/s-0028-1109478. [PubMed: 20094978].
. Lee WJ, Chu JS, Houng SJ, Chung MF, Wang SM, Chen KM. Breast cancer angiogenesis: a quantitative morphologic and Doppler imaging study. Ann Surg Oncol. 1995;2(3):246–51. [PubMed: 7543800].
93. Kumar A, Srivastava V, Singh S, Shukla RC. Color Doppler ultrasonography for treatment response prediction and evaluation in breast cancer. Future Oncol. 2010;6(8):1265–78. doi: 10.2217/fon.10.93. [PubMed: 20799873].
94. Campi R, Carlotto M, Gorreta L, Tragni C, Belli L, Tufarulo L, et al. [The role of color Doppler echography in the diagnosis of breast tumors]. Radiol Med. 1990;79(3):182–4. [PubMed: 2186439].
95. Grischke EM, von Fournier D, Sohn C, Wallwiener D, Bastert G. [Diagnostic value of Doppler ultrasound in evaluation of breast tumors]. Zentralbl Gynakol. 1996;118(10):553–9. [PubMed: 8999709].
96. McNicholas MM, Mercer PM, Miller JC, McDermott EW, O’Higgins NJ, MacErlean DP. Color Doppler sonography in the evaluation of palpable breast masses. AJR Am J Roentgenol. 1993;161(4):765–71. doi: 10.2214/ajr.161.4.8372754. [PubMed: 8372754].
97. del Cura JL, Elizagaray E, Zabala R, Legorburu A, Grande D. The use of unenhanced Doppler sonography in the evaluation of solid breast lesions. AJR Am J Roentgenol. 2005;184(6):1788–94. doi: 10.2214/ajr.184.6.01841788. [PubMed: 15908531].
Cosgrove DO, Kedar RP, Bamber JC, al-Murrani B, Davey JB, Fisher C, et al. Breast diseases: color Doppler US in differential diagnosis. Radiology. 1993;189(1):99–104. doi: 10.1148/radiology.189.1.8372225. [PubMed: 8372225].
99. Cosgrove DO, Bamber JC, Davey JB, McKinna JA, Sinnett HD. Color Doppler signals from breast tumors. Work in progress. Radiology. 1990;176(1):175–80. doi: 10.1148/radiology.176.1.2191364. [PubMed: 2191364].
Busilacchi P, Draghi F, Preda L, Ferranti C. Has color Doppler a role in the evaluation of mammary lesions?. J Ultrasound. 2012;15(2):93–8. doi: 10.1016/j.jus.2012.02.007. [PubMed: 23396684].
101. Stanzani D, Chala LF, Barros N, Cerri GG, Chammas MC. Can Doppler or contrast-enhanced ultrasound analysis add diagnostically important information about the nature of breast lesions?. Clinics (Sao Paulo). 2014;69(2):87–92. doi: 10.6061/clinics/2014(02)03. [PubMed: 24519198].
Refbacks
- There are currently no refbacks.
© Copyright PJR 2008- |