GIANT PSEUDOANGIOMATOUS STROMAL HYPERPLASIA IN A YOUNG GIRL: A CASE REPORT.

Sheeza Imtiaz, Nasreen Naz, Anila Rahim, Ayesha Walid

Abstract


Vuitch et al first reported Pseudoangiomatous stromal hyperplasia (PASH) as a benign proliferative breast disease. It is thought to be hormone sensitive and represents a hyper-response to estrogen and progesterone resulting in myofibroblast proliferation. It is commonly reported histologically in breast biopsy specimen. It usually occurs in peri and premenopausal women, but may also occur in adolescent, postmenopausal women on hormone replacement therapy and rarely in men. Definitive diagnosis is challenging as it mimics with other benign breast lesions. Less than 20 cases of diffuse and less than 200 cases of tumorous PASH has been reported so far. Its association with malignancy is very rare. Here we report a case of giant pseudoangiomatous stromal hyperplasia in a young girl presented with asymmetrical enlargement of her right breast.


Full Text:

PDF

References


Vuitch MF, Rosen PP, Erlandson RA. Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol. 1986;17(2):185–91.

Krawczyk N, Fehm T, Ruckhäberle E, et al.: Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia (PASH) Causing Gigantomastia in a 33-Year-Old Pregnant Woman: Case Report. Breast Care (Basel). 2016;11(5): 356–58.

Raza, Fatima K, Tariq M. Breast Imaging Chameleon: Pseudoangiomatous Stromal Hyperplasia Presenting as Breast Malignancy. Cureus. 2020;12(5):e8359.

G. C. Hargaden, E. D. Yeh, D. Georgian-Smith et al., “Analysis of the mammographic and sonographic features of pseudoangiomatous stromal hyperplasia,” American Journal of Roentgenology. 2008;191(2): 359–63.

Jones KN, Glazebrook KN, Reynolds C. Pseudoangiomatous stromal hyperplasia: imaging findings with pathologic and clinical correlation. AJR Am J Roentgenol. 2010;195(4):1036–42.

Bowman E, Opera G, Okoli J et al. Pseudoangiolmatous stromal hyperplasia of the breast: a series of 24 patients. Breast J. 2012;18:242-47.

Donk WA, Oostenbroek RJ, Storm RK, Westenend PJ, Plaisier PW. Pseudoangiomatous stromal hyperplasia: diagnosis, treatment and follow-up; description of a case-series. Open Breast Cancer J. 2011;3:18–23.


Refbacks

  • There are currently no refbacks.


© Copyright PJR 2008-