Sheeza Imtiaz, Nasreen Naz, Anila Rahim, Ayesha Walid


Vuitch et al first reported Pseudoangiomatous stromal hyperplasia (PASH) as a benign proliferative breast disease. It is thought to be hormone sensitive and represents a hyper-response to estrogen and progesterone resulting in myofibroblast proliferation. It is commonly reported histologically in breast biopsy specimen. It usually occurs in peri and premenopausal women, but may also occur in adolescent, postmenopausal women on hormone replacement therapy and rarely in men. Definitive diagnosis is challenging as it mimics with other benign breast lesions. Less than 20 cases of diffuse and less than 200 cases of tumorous PASH has been reported so far. Its association with malignancy is very rare. Here we report a case of giant pseudoangiomatous stromal hyperplasia in a young girl presented with asymmetrical enlargement of her right breast.

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