DIAGNOSTIC ACCURACY OF MRI IN PATIENTS WITH ELEVATED PSA LEVELS IN PREDICTING PROSTATIC CARCINOMA, KEEPING HISTOPATHOLOGY AS GOLD STANDARD.

Dr. Muhammad Din; Dr. Muhammad Wasim Awan; Dr. Shaghaf Iqbal; Dr. Zunaira Rafique; Dr. Samina Samina; Dr. Mansoor Ghani

DIAGNOSTIC ACCURACY OF MRI IN PATIENTS WITH ELEVATED PSA LEVELS IN PREDICTING PROSTATIC CARCINOMA, KEEPING HISTOPATHOLOGY AS GOLD STANDARD.

Dr. Muhammad Din, Dr. Muhammad Wasim Awan, Dr. Shaghaf Iqbal, Dr. Zunaira Rafique, Dr. Samina Samina, Dr. Mansoor Ghani

Abstract

ABSTRACT

INTRODUCTION

OBJECTIVE: To determine the diagnostic accuracy of MRI in diagnosis of prostatic carcinoma in patients with raised PSA levels keeping histopathology as gold standard.

Materials and methods: This cross-sectional validation study was conducted in Department of Radiology KRL Hospital Islamabad, which is equipped with PHILIPS MULTIVA 1.5 TESLA MRI machine after taking permission from The Hospital Ethical Committee for six months from 01-02-20 till 01-08-20. A total of 121 patients were selected with raised PSA levels, who later on underwent MRI with different sequences including T1WI, T2WI, DWI, and dynamic contrast enhanced sequences after giving I/V contrast followed by biopsy and histopathology. Data was collected on a proforma and later on analyzed on SPSS Version 16 while the results were analyzed by descriptive and inferential statistics.

Results:

Out of 121 patients with mean age 51.23 years with the standard deviation of ±8.57. Out of 121 patients, sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of MRI for the diagnosis of prostate carcinoma by taking histopathology as gold standard was found to be 92.3%, 82.7%, 94.4%, 77.4% and 90% respectively.

Conclusion:

It is concluded that magnetic resonance imaging is a highly sensitive, specific and rapid method for diagnosing prostate cancer which has potential to complement the current reference standard of histopathology and increase its overall sensitivity.

KEY WORDS: Prostate carcinoma, prostate specific antigen, magnetic resonance imaging and histopathology.

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References

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