MINI-REVIEW: ROLE OF 18FDG PET/CT IMAGING IN VASCULITIS AND POLYMYALGIA RHEUMATICA

Maseeh uz Zaman; Nosheen Fatima; Sidra Zaman; Areeba Zaman; Unaiza Zaman; Anwar Ahmed

MINI-REVIEW: ROLE OF 18FDG PET/CT IMAGING IN VASCULITIS AND POLYMYALGIA RHEUMATICA

Maseeh uz Zaman, Nosheen Fatima, Sidra Zaman, Areeba Zaman, Unaiza Zaman, Anwar Ahmed

Abstract

Autoimmune vasculitis has two major variants Takayasu arteritis (TA) and giant cell arteritis (GCA) which often coexists with polymyalgia rheumatica (PMR). In recent days, the role of ¹⁸FDG-PET/CT imaging has been evaluated in diagnosis, disease monitoring and metabolic response assessment in these patients. This mini-review would focus on various diagnostic strategies, guidelines for standardized ¹⁸FDG PET/CT acquisition and interpretation, pitfalls and challenges in its use in current clinical practice.

Key Words: Vasculitis; Giant Cel Arteritis; Takayasu Arteritis; ¹⁸FDG PET/CT; diagnosis; response assessment; standardized

Full Text:

PDF

References

Jennette JC, Falk RJ, Bacon PA, et al. 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65:1–11

. van der Geest KSM, Sandovici M, van Sleen Y, et al. Review: what is the current evidence for disease subsets in giant cell arteritis? Arthritis Rheumatol. 2018;70: 1366–1376

. Crowson CS, Matteson EL, Myasoedova E, et al. The lifetime risk of adult-onset rheumatoid arthritis and other inflammatory autoimmune rheumatic diseases. Arthritis Rheum. 2011;63:633–639

. Watts RA, Robson J. Introduction, epidemiology and classification of vasculitis. Best Pract Res Clin Rheumatol. 2018;32:3–20.

. Nielsen BD, Hansen IT, Keller KK, Therkildsen P, Gormsen LC, Hauge E-M. Diagnostic accuracy of ultrasound for detecting large-vessel giant cell arteritis using FDG PET/CT as the reference. Rheumatology. 2020;59:2062–2073

. https://www.medpagetoday.com/rheumatology/generalrheumatology/54005 (visited on 12.10.2023)

. . Dejaco C, Ramiro S, Duftner C, et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice. Ann Rheum Dis. 2018;77:636–643.

. Slart RHJA, Nienhuis PH, Glaudemans AWJM, Brouwer E, Gheysens O, van der Geest KSM. Role of 18F-FDG PET/CT in Large Vessel Vasculitis and Polymyalgia Rheumatica. J Nucl Med. 2023 Apr;64(4):515-521. doi: 10.2967/jnumed.122.265016.

. Slart RHJA, Glaudemans A, Chareonthaitawee P, Treglia G, Bessond FL, Bleyd TA, et al. FDG-PET/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC. Eur J Nucl Med Mol Imaging 2018; 45:1250–69 (https://doi.org/10.1007/s00259-018-3973-8)

. Dejaco C, Ramiro S, Bond M, Bosch P, Ponte C, Mackie SL, et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update Annals of the Rheumatic Diseases Published Online First: 07 August 2023. doi: 10.1136/ard-2023-224543

. Blockmans D, Bley T, Schmidt W. Imaging for large-vessel vasculitis. Curr Opin Rheumatol. 2009;21:19–28.

. Besson FL, Parienti J-J, Bienvenu B, et al. Diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography in giant cell arteritis: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2011;38:1764–1772

. Barra L, Kanji T, Malette J, Pagnoux C. Imaging modalities for the diagnosis and disease activity assessment of Takayasu’s arteritis: a systematic review and metaanalysis. Autoimmun Rev. 2018;17:175–187.

. Kermani TA, Warrington KJ, Cuthbertson D, et al. Disease relapses among patients with giant cell arteritis: a prospective, longitudinal cohort study. J Rheumatol. 2015;42:1213–1217

. Nielsen BD, Gormsen LC, Hansen IT, Keller KK, Therkildsen P, Hauge E-M. Three days of high-dose glucocorticoid treatment attenuates large-vessel 18F-FDG uptake in large-vessel giant cell arteritis but with a limited impact on diagnostic accuracy. Eur J Nucl Med Mol Imaging. 2018;45:1119–1128.

. van der Geest KSM, Treglia G, Glaudemans AWJM, et al. Diagnostic value of [ 18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2021;48:3886–3902

. Galli E, Muratore F, Mancuso P, et al. The role of PET/CT in disease activity assessment in patients with large vessel vasculitis. Rheumatology. 2022;61:4809–4816

. van der Geest KSM, Treglia G, Glaudemans AWJM, et al. Diagnostic value of [18F]FDG-PET/CT in polymyalgia rheumatica: a systematic review and metaanalysis. Eur J Nucl Med Mol Imaging. 2021;48:1876–1889

Refbacks

There are currently no refbacks.