KNOWLEDGE CHALLENGE

Abstract

FDG PET/CT studies of two brothers performed in September 2022 (A) and October 2024 for work up of severe anemia in both. Previous medical history is not significant either. Their mother had had adenocarcinoma of ascending colon diagnosed at age of 51 Years and had had right colectomy and survived for 19 years (died of hemorrhagic stroke). Their eldest brother died of metastatic prostate cancer at age of 68 years. Their one niece was diagnosed with triple negative breast cancer at age of 40 Yr, has had modified radical mastectomy and is a survivor.

Questions

1. What is your diagnosis?
2. Which malignancy is primarily associated with your diagnosis?
3. What other malignancies are associated?
4. What is the genetic cause?
5. What is inheritance pattern?
6. What age of screening is recommended?
7. Which test is used to diagnose pathology sample?
8. What is recommended prophylactic strategy for positive family members?