EFFECT OF OUTFLOW OBSTRUCTION ON THE RELATIVE RENAL FUNCTION ESTIMATION WITH 99MTC-MAG-3 AND 99MTC-DMSA

Abstract

BACKGROUND: Several areas of controversy still exist in the selective preference of the method for estimation of relative renal function in patients with outflow obstruction. OBJECTIVES: The aim of this study was to compare the estimation of relative renal function by 99mTc-MAG-3 and 99mTc-DMSA in patients with unilateral outflow obstruction. METHODS: 99mTc-DMSA scintigraphy was done on 34 patients with outflow obstruction on 99mTc-MAG3 scintigraphy. Relative renal functions were calculated and effect of obstruction on the relative renal function was compared. RESULTS: Good correlation was observed in the estimation of relative renal function estimated by both the methods. One third of the patients had overestimated renal function on 99mTc-DMSA scintigraphy, however the difference was not statistically significant. CONCLUSION: Although 99mTc-DMSA and 99mTc-MAG3 relative renal function estimation show a statistically significant correlation, the over estimations of relative renal function by 99mTc-DMSA in a significant number of case with outflow obstruction needs further clarification. Key words : DMSA, MAG3, Relative Renal Function, Renal Outflow Obstruction.