Sanjay Mhalasakant Khaladkar, Dinesh Chouhan, Foram Doshi


Iron overload can occur in beta thalassemia. The iron overload can damage liver ,heart and endocrine organs. Non- endocrine complications due to iron overload are liver fibrosis and cirrhosis , skeletal manifestations and dilated cardiomyopathy .Endocrine manifestations are pituitary insufficiency, failure of sexual maturation, delayed puberty and hypogonadism ,diabetes mellitus and glucose intolerance due to pancreatic insufficiency, dyslipidaemia, hypoadrenalism, hypothyroidism and hypoparathyroidism. Hypoparathyroidism is seen upto 6.7 % of thalassemia major(TM) patients and is the most prevalent endocrine complications of thalassemia major . Diffuse hepatic calcification and calcification in the brain occur in beta thalassemia due to hypoparathyroidism . Isolated intracerebral calcification due to hypoparathyroidism has been reported previously. Isolated hepatic calcification is infrequent with only one reported case in thalassemia. We report the first case of an 18- year old beta-thalassemia major patient,  with hypoparathyroidism with extensive diffuse hepatic calcification and brain calcification.

Full Text:



Inati A, Noureldine MA, Mansour A, Abbas HA.Endocrine and bone complications in β-thalassemia intermedia: current understanding and treatment.Biomed Res Int. 2015;2015:813098PMID: 25834825 PMCID: PMC4365366

Rund D, Rachmilewitz E. B-Thalassemia. N Engl J Med. 2005 Sep 15;353(11):1135-46

Siegelman ES, Mitchell DG, Semelka RC.Abdominal iron deposition: metabolism, MR findings, and clinical importance.Radiology. 1996 Apr;199(1):13-22.PMID: 8633135.

Wood J, Enriquez C, Ghugre N, et al. MRI R2 and R2* mapping accurately estimates hepatic iron concentration inb transfusion-dependant thalassaemia and sickle cell disease patients. Blood 2005:106;1460-5.

Saki F, Bordbar MR, Imanieh MH, Karimi M.Diffuse hepatic calcifications in a transfusion-dependent patient with Beta-thalassemia: a case report.Iran J Med Sci. 2013 Sep;38(3):271-4. PMID: 24174700 PMCID: PMC3808953

De Sanctis V, Vullo C, Bagni B, Chiccoli L.Hypoparathyroidism in beta-thalassemia major. Clinical and laboratory observations in 24 patients. Acta Haematol. 1992;88:105-8. PubMed PMID: 1466190.

Karimi M, Rasekhi AR, Rasekh M, Nabavizadeh SA, Assadsangabi R, Amirhakimi GH.Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major. Eur J Radiol. 2009;70:481-4. doi: 10.1016/j.ejrad.2008.02.003. PubMed PMID: 18367361.

Kinjo K, Yamashiro M, Akamine K, Kinjo M, Oshiro M. Diffuse hepatocellular calcification developing in a patient on chronic hemodialysis after ischemic hepatitis. Intern Med. 2007; 46:1729-33. PubMed PMID: 17938529.

Raza A, Ahmed K, Rood RP. Diffuse hepatic calcification following ischemic insult in the setting of impaired renal function. Clin Gastroenterol Hepatol. 2012;10:A24. PubMed PMID:22051628.


  • There are currently no refbacks.

© Copyright PJR 2008-