ESTIMATION OF PITUITARY GLAND VOLUME BY MRI AND ITS CORRELATION WITH SEX AND AGE

Sanobar Bughio, Muhammad Ali, Arsalan Manzoor Mughal

Abstract


Objective: To determine measurements of pituitary gland volume in subjects with normal pituitary gland ages 10 to 70 years presenting at Radiology Department, Ziauddin Hospital, Clifton Karachi. 
Methods:  Total 290 subjects of different age groups with normal pituitary gland volume were evaluated using T1 weighted Magnetic Resonance Imaging. Mid-sagittal and coronal planes were used to measure the height, width, and depth of the pituitary gland, while the volume was calculated using these parameters. Data was stratified into nine groups on the basis of age and sex to observe the differences. 

Results: We recruited 290 subjects (152 males, 138 females). Females had significantly greater pituitary depth (1.25±0.221cm) and volume (0.47±0.123cm3) compared to males. The height of the gland was minimum (0.53cm) in first decade of life, maximum (0.60cm) in the second decade and progressively decreased till the sixth decade. The volume of the gland was least in the first decade of life (0.36±0.11cm3) and maximum in the third decade (0.49±0.111cm3).

Conclusion:  We have provided reference values for the normal pituitary gland dimensions in a population of Karachi which will aid in assessment and diagnosis of patients with abnormalities in pituitary function.


Full Text:

PDF

References


Sahni D, Jit I, Bhansali A, others. Weight and dimensions of the pituitary in northwestern Indians. Pituitary. 2006;9(1):19–26.

Hong GK, Payne SC, Jane JA. Anatomy, Physiology, and Laboratory Evaluation of the Pituitary Gland. Otolaryngol Clin North Am. 2016 Feb;49(1):21–32.

Doraiswamy PM, Potts JM, Axelson DA, Husain MM, Lurie SN, Na C, et al. MR assessment of pituitary gland morphology in healthy volunteers: age-and gender-related differences. Am J Neuroradiol. 1992;13(5):1295–9.

Zrazhevskiy P, Sena M, Gao X. Designing multifunctional quantum dots for bioimaging, detection, and drug delivery. Chem Soc Rev. 2010;39(11):4326–54.

Forbes K, Karis J, White WL. Imaging of the pituitary gland. Barrow Q. 2002;18(3):9–19.

Ikram MF, Sajjad Z, Shokh I, Omair A. Pituitary height on magnetic resonance imaging observation of age and sex related changes. JPMA J Pak Med Assoc. 2008;58(5):261.

Fink AM, Vidmar S, Kumbla S, Pedreira CC, Kanumakala S, Williams C, et al. Age-related pituitary volumes in prepubertal children with normal endocrine function: volumetric magnetic resonance data. J Clin Endocrinol Metab. 2005;90(6):3274–8.

Janssen YJH, Doornbos J, Roelfsema F. Changes in muscle volume, strength, and bioenergetics during recombinant human growth hormone (GH) therapy in adults with GH deficiency 1. J Clin Endocrinol Metab. 1999;84(1):279–84.

DENK CC, ÖNDEROGLU S, Sezgin I, GÜRCAN F. Height of normal pituitary gland on MRI: differences between age groups and sexes. Okajimas Folia Anat Jpn. 1999;76(2-3):81–7.

Elster AD, Chen MY, Williams 3rd DW, Key LL. Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology. 1990;174(3):681–5.

Argyropoulou MI, Kiortsis DN, Metafratzi Z, Efremidis SC. Magnetisation transfer imaging of the normal adenohypophysis: the effect of sex and age. Neuroradiology. 2001;43(4):305–8.

Roldan-Valadez E, Garcia-Ulloa AC, Gonzalez-Gutierrez O, Martinez-Lopez M, others. 3D volumetry comparison using 3T magnetic resonance imaging between normal and adenoma-containing pituitary glands. Neurol India. 2011;59(5):696.

Naik D, D PR, Srinath MG, Kumar AA. Pituitary Gland Assessment by MR Volumetry in the Normal Indian Adolescent Population. Int J Med Imaging. 2015 Nov 3;3(6):105.

Tsunoda A, Okuda O, Sato K. MR height of the pituitary gland as a function of age and sex: especially physiological hypertrophy in adolescence and in climacterium. Am J Neuroradiol. 1997;18(3):551–4.

Ibinaiye PO, Olarinoye-Akorede S, Kajogbola O, Bakari AG. Magnetic resonance imaging determination of normal pituitary gland dimensions in Zaria, Northwest Nigerian population. J Clin Imaging Sci [Internet]. 2015 [cited 2017 Mar 2];5. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485185/

Lamichhane TR, Pangeni S, Paudel S, Lamichhane HP. Age and Gender Related Variations of Pituitary Gland Size of Healthy Nepalese People Using Magnetic Resonance Imaging. Am J Biomed Eng. 2015;5(4):130–5.

MacMaster FP, Keshavan M, Mirza Y, Carrey N, Upadhyaya AR, El-Sheikh R, et al. Development and sexual dimorphism of the pituitary gland. Life Sci. 2007 Feb 13;80(10):940–4.

Yamamoto A, Oba H, Furui S. Influence of age and sex on signal intensities of the posterior lobe of the pituitary gland on T1-weighted images from 3 T MRI. Jpn J Radiol. 2013;31(3):186–91.

Hayakawa K, Konishi Y, Matsuda T, Kuriyama M, Konishi K, Yamashita K, et al. Development and aging of brain midline structures: assessment with MR imaging. Radiology. 1989;172(1):171–7.

Sharafuddin MJ, Luisiri A, Garibaldi LR, Fulk DL, Klein JB, Gillespie KN, et al. MR imaging diagnosis of central precocious puberty: importance of changes in the shape and size of the pituitary gland. AJR Am J Roentgenol. 1994;162(5):1167–73.

Lurie SN, Doraiswamy PM, Husain MM, Boyko OB, Ellinwood EH, Figiel Jr GS, et al. In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age. J Clin Endocrinol Metab. 1990;71(2):505–8.


Refbacks

  • There are currently no refbacks.


© Copyright PJR 2008-