Sanobar Bughio, Muhammad Ali, Arsalan Manzoor Mughal


Objective: To determine measurements of pituitary gland volume in subjects with normal pituitary gland ages 10 to 70 years presenting at Radiology Department, Ziauddin Hospital, Clifton Karachi. 
Methods:  Total 290 subjects of different age groups with normal pituitary gland volume were evaluated using T1 weighted Magnetic Resonance Imaging. Mid-sagittal and coronal planes were used to measure the height, width, and depth of the pituitary gland, while the volume was calculated using these parameters. Data was stratified into nine groups on the basis of age and sex to observe the differences. 

Results: We recruited 290 subjects (152 males, 138 females). Females had significantly greater pituitary depth (1.25±0.221cm) and volume (0.47±0.123cm3) compared to males. The height of the gland was minimum (0.53cm) in first decade of life, maximum (0.60cm) in the second decade and progressively decreased till the sixth decade. The volume of the gland was least in the first decade of life (0.36±0.11cm3) and maximum in the third decade (0.49±0.111cm3).

Conclusion:  We have provided reference values for the normal pituitary gland dimensions in a population of Karachi which will aid in assessment and diagnosis of patients with abnormalities in pituitary function.

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